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PIPs Study
Sub Study

If you decide to take part in the optional sub-study, this is what your participation will involve:

  • Lumbar puncture at the Royal Melbourne Hospital


We will check your blood sample and MRI scan to make sure it is safe for you to undergo a lumbar puncture.

We will use a lumbar puncture to collect cerebrospinal fluid (CSF) to investigate the same proteins involved in schizophrenia and brain development that we are measuring in blood. CSF is a fluid that flows in and around the hollow spaces of the brain and spinal cord and is collected from a gap between two vertebrae in the lower spine. We need CSF because it better reflects the biochemical contents of the brain than blood. This is because there is a barrier between circulating blood system and the brain and spinal cord that prevents many molecules from entering the brain. The CSF will provide ‘a window’ into what is happening in the brain.

Lumbar punctures are a routine medical procedure, and are very common in countries such as Germany and those in Scandinavia.

The lumbar puncture will be done by a doctor trained in this procedure and involves lying still on your back. The procedure will take roughly 15 minutes to perform. 

In total, the sub-study will take 1-2 hours. You will be reimbursed $220 (via an e-Gift card of your choosing) for your time.

If you would like further information about the sub-study, please read the Participation Information Form below:

We also have an optional sub-study component of our PIPs research that you can choose to participate in on a separate day after your first visit with us. You do not have to take part in the sub-study to participate in the PIPs study.

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