Melbourne
Neuropsychiatry
Centre
University of Melbourne and
Melbourne Health
MOOD - PSYCHOSIS SPECTRUM
The Mood- Psychosis Spectrum group within the Psychosis Studies research stream aims to understand links between the brain, cognition and behaviour in bipolar disorder and related illnesses on the mood-psychosis spectrum. We focus on characterising neurocognitive and social cognitive functioning in these illnesses and ascertaining their clinical and neurobiological correlates using behavioural, neuroimaging and psychophysiological techniques.
Lisa Furlong (PhD Candidate)
Elysha Ringin (PhD Candidate)
MEMBERS:
Dr James Karantonis (Lab Manager)
Dr Sean Carruthers (Research Fellow)
Georgia Caruana (PhD Candidate)
Reuben Dyer (PhD Candidate)
ICON-BD STUDY
ICoN-BD is short for 'Identifying Correlates of Neuropsychological functioning in Bipolar Disorder'. Using a combination of physical, neurological, clinical and cognitive assessments, this research project aims to get a better understanding of the reasons for the variability in thinking and emotional skills in people with bipolar disorder.
In doing so, this research will help us to better understand bipolar disorder itself, and to develop more effective and targeted intervention strategies for those that experience thinking skill and emotional difficulties
KEY PUBLICATIONS
Van Rheenen T.E., Cropley VL., Wells R., Bruggemann J., Swaminathan V, Sundram S, Weinberg W., Jacomb I, Lenroot R, Pereira AM, Zalesky A, Bousman C, Shannon Weickert C, Weickert TW, Pantelis P. (2020) Cognitive Reserve Attenuates Age-Related Cognitive Decline in the Context of Accelerated Brain Ageing in Schizophrenia-Spectrum Disorders. Psychological Medicine, 50, 1475-1489
Karantonis J, Rossell S.L, Carruthers S, Sumner P, Hughes M, Green MJ, Pantelis C, Burdick K.E, Cropley V, Van Rheenen TE. (2020) Cognitive validation of cross-diagnostic cognitive subgroups on the schizophrenia-bipolar spectrum. Journal of Affective Disorders, 266, 710-721
Van Rheenen T.E, Cropley VL, Wells R, Bruggemann J., Swaminathan V, Sundram S, Weinberg W., Jacomb I, Lenroot R, Pereira AM, Zalesky A, Bousman C, Shannon Weickert C, Weickert TW, Pantelis P. (2018). Widespread volumetric reductions in schizophrenia and schizoaffective patients displaying compromised cognitive abilities. Schizophrenia Bulletin, 44(3):560-574
Van Rheenen T.E., Lewandowski KE., Tan, E., Ospina, L., Ongur D, Malhotra A., Neill, E, Gurvich, E., Pantelis, C., Rossell SL., Burdick KE. (2017). Characterising cognitive heterogeneity on the schizophrenia – bipolar spectrum. Psychological Medicine. 47, 1848-1864
Van Rheenen TE, Lewandowski KE, Bauer I, Kapczinski F., Miskowiak K., Burdick, KE, Balanza-Martinez, V. Current understandings of the trajectory and emerging correlates of cognitive impairment in bipolar disorder: an overview of evidence (2020). Bipolar Disorders, 22:13–27
Van Rheenen, T.E., Lewandowski, K.E, Lipschitz J.M, Burdick K.E. (2019) Conducting Clinical Studies Targeting Cognition in Psychiatry: Guiding Principles and Design, CNS Spectrums, 24, 16-21
Van Rheenen, TE, Ganella E., Bauer I and Bartholemeusz C. (2019). Characterisation of social cognitive deficits on the schizophrenia -bipolar spectrum: an overview of current evidence, In Lewandowski, K and Moustafa, A.M. eds. Social Cognition in Psychosis. Elsevier Inc, New York, p. 2-36
Furlong L.S, Rossell S.L, Caruana, G.F, Cropley V.L, Hughes M, Van Rheenen T.E. (2021) The activity and connectivity of the facial emotion processing neural circuitry in bipolar disorder: a systematic review. Journal of Affective Disorders, 279, 518-548.
James A Karantonis, Sean P Carruthers, Susan L Rossell, Christos Pantelis, Matthew Hughes, Cassandra Wannan, Vanessa Cropley, Tamsyn E Van Rheenen, A Systematic Review of Cognition-Brain Morphology Relationships on the Schizophrenia-Bipolar Disorder Spectrum, Schizophrenia Bulletin, 2021; https://doi.org/10.1093/schbul/sbab054