DEPRESSION AND ANXIETY

We study the brain systems involved in human emotional experience and associated cognition, including how such relationships are affected in people with mood and anxiety disorders. On a practical level, our goal is to develop better brain-based models of these common mental health disorders that may have future utility in optimising their treatment. More fundamentally, we seek to understand how the activity of large-scale brain systems contributes to individual differences in emotional experience – questions that are uniquely addressed in human functional brain imaging (‘fMRI’) research. Leveraging this technology, our projects integrate psychological experimentation with measurements of emotional behaviour and self-report, as well as peripheral physiological monitoring. We have successfully integrated our research platform in clinical studies of help-seeking populations, including NHMRC-funded randomised clinical trials.

MEMBERS:

A/Prof Christopher Davey (Co-Investigator; Orygen)

Lisa Incerti (Project Coordinator)

Laura Finlayson (PhD Candidate)

Micah Cearns (RA)

Hannah Savage (PhD Candidate)

Patrick Laing (PhD Candidate)

Alec Jamieson (PhD Candidate)

Rachel Brodie (RA)

Rebekah Delahoy (RA)

A NEURAL SYSTEM MODEL OF FEAR DYSREGULATION IN ANXIETY DISORDERS

Information to come.

Funding: NHMRC Project Grant (ID 1161897)

Collaborators: 

Davey CG, Harrison BJ. (2018) The brain’s center of gravity: how the default mode network helps us to understand the self. World Psychiatry 17(3):278–279.

Via E et al. (2018) Ventromedial prefrontal cortex activity and pathological worry in generalised anxiety disorder. British Journal of Psychiatry 213(1):437-443.

Fullana MA et al. (2018) Fear extinction in the human brain: a meta-analysis of fMRI studies in healthy participants. Neuroscience & Biobehavioral Reviews 88: 16-25.

Harrison BJ et al. (2017) Human ventromedial prefrontal cortex and the positive affective processing of safety signals. Neuroimage 152:12–18.

Stephanou K et al. (2017) Hard to look on the bright side: neural correlates of impaired emotion regulation in depressed youth. Social Cognitive and Affective Neuroscience 12(7):1138–1148.

Davey CG et al. (2017) A Brain Model of Disturbed Self-Appraisal in Depression. American Journal of Psychiatry 174(9):895–903.

Fullana MA et al. (2016) Neural signatures of human fear conditioning: an updated and extended meta-analysis of fMRI studies. Molecular Psychiatry 21(4):500–508.

Davey CG et al. (2016) Mapping the self in the brain’s default mode network. Neuroimage 132:390–397.

Stephanou K et al. (2016) Brain functional correlates of emotion regulation across adolescence and young adulthood. Human Brain Mapping 37(1):7–19.

KEY PUBLICATIONS

Melbourne

Neuropsychiatry

Centre

University of Melbourne and

Melbourne Health

Melbourne Neuropsychiatry Centre

Level 3, Alan Gilbert Building

161 Barry Street

Carlton, Victoria, 3053

AUSTRALIA